Tisson Mathew is the Founder and CEO of Skypoint, an agentic AI platform transforming healthcare operations through unified data and AI Agents. Since founding the company in 2020, he has led Skypoint’s rapid growth, earning recognition on the Deloitte Fast 500 (two consecutive years) and Inc. 5000 as one of the fastest-growing AI companies.
Skypoint’s HITRUST r2–certified platform integrates data from over 250 clinical and operational systems and delivers 15+ AI-powered applications powered by skyAgent—its role-based, workflow-embedded AI framework. SkyAgent enables healthcare leaders and frontline teams to automate insights, improve financial performance, and drive measurable operational impact.
With over 20 years of experience in healthcare, cloud, and enterprise technology, Tisson previously held senior leadership roles at Alignment Healthcare, Cambia Health Solutions, Amazon, and Intel Labs. He holds a Master of Science in Computer Science from Oregon Health & Science University.
